Low Birth Weight, Cumulative Obesity Dose, and the Risk of Incident Type 2 Diabetes.

ABSTRACT:

Background

Obesity history may provide a better understanding of the contribution of obesity to T2DM risk.

Methods

17,634 participants from the 1958 National Child Development Study were followed from birth to 50 years. Cumulative obesity dose, a measure of obesity history, was calculated by subtracting the upper cut-off of the normal BMI from the actual BMI at each follow-up and summing the areas under the obesity dose curve. Hazard ratios (HRs) for diabetes were calculated using Cox regression analysis. Three separate models compared the predictive ability of cumulative obesity dose on diabetes risk with the time-varying BMI and last BMI.

Results

In final models, 341 of 15,043 (2.27%) participants developed diabetes; male sex and low birth weight were significant co

SUBMITTER: Feng C 

PROVIDER: S-EPMC5818910 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature