Genetic Risk Score Analysis in Early-Onset Bipolar Disorder.

ABSTRACT:

Objective

In this study, we performed a candidate genetic risk score (GRS) analysis of early-onset bipolar disorder (BD).

Methods

Treatment of Early Age Mania (TEAM) study enrollment and sample collection took place from 2003 to 2008. Mayo Clinic Bipolar Biobank samples were collected from 2009 to 2013. Genotyping and analyses for the present study took place from 2013 to 2014. The diagnosis of BD was based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. Eight single-nucleotide polymorphisms (SNPs), previously reported in genome-wide association studies to be associated with BD, were chosen for GRS analysis in early-onset bipolar disease. These SNPs map to 3 genes: CACNA1C (calcium channel, voltage-dependent, L type, alpha 1C

SUBMITTER: Croarkin PE 

PROVIDER: S-EPMC5818996 | biostudies-literature | 2017 Nov-Dec

REPOSITORIES: biostudies-literature