Cumulative exposure to environmental pollutants during early pregnancy and reduced fetal growth: the Project Viva cohort.

ABSTRACT:

Background

Reduced fetal growth is associated with perinatal and later morbidity. Prenatal exposure to environmental pollutants is linked to reduced fetal growth at birth, but the impact of concomitant exposure to multiple pollutants is unclear. The purpose of this study was to examine interactions between early pregnancy exposure to cigarette smoke, traffic pollution, and select perfluoroalkyl substances (PFASs) on birth weight-for-gestational age (BW/GA).

Methods

Among 1597 Project Viva mother-infant pairs, we assessed maternal cigarette smoking by questionnaire, traffic pollution at residential address by black carbon land use regression model, and plasma concentration of select PFASs in early pregnancy. We calculated sex-specific BW/GA z-scores, an index of fetal growth,

SUBMITTER: Rokoff LB 

PROVIDER: S-EPMC5819079 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature