Genome mining for peptidases in heat-tolerant and mesophilic fungi and putative adaptations for thermostability.

ABSTRACT:

Background

Peptidases (EC 3.4) consist of a large group of hydrolytic enzymes that catalyze the hydrolysis of proteins accounting for approximately 65% of the total worldwide enzyme production. Peptidases from thermophilic fungi have adaptations to high temperature that makes them adequate for biotechnological application. In the present study, we profiled the genomes of heat-tolerant fungi and phylogenetically related mesophilic species for genes encoding for peptidases and their putative adaptations for thermostability.

Results

We generated an extensive catalogue of these enzymes ranging from 241 to 820 peptidase genes in the genomes of 23 fungi. Thermophilic species presented the smallest number of peptidases encoding genes in relation to mesophilic species, and the pepti

SUBMITTER: de Oliveira TB 

PROVIDER: S-EPMC5819190 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature