Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease.

ABSTRACT:

Background

Simultaneous consideration of two neuropathological traits related to Alzheimer's disease (AD) has not been attempted in a genome-wide association study.

Methods

We conducted genome-wide pleiotropy analyses using association summary statistics from the Beecham et al. study (PLoS Genet 10:e1004606, 2014) for AD-related neuropathological traits, including neuritic plaque (NP), neurofibrillary tangle (NFT), and cerebral amyloid angiopathy (CAA). Significant findings were further examined by expression quantitative trait locus and differentially expressed gene analyses in AD vs. control brains using gene expression data.

Results

Genome-wide significant pleiotropic associations were observed for the joint model of NP and NFT (NP + NFT) with the single-nucleotide

SUBMITTER: Chung J 

PROVIDER: S-EPMC5819208 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature