Gut microbiota trajectory in early life may predict development of celiac disease.

ABSTRACT:

Background

To investigate whether alterations in the developing intestinal microbiota and immune markers precede celiac disease (CD) onset in infants at familial risk of developing the disease.

Methods

A nested case-control study was carried out as part of a larger prospective cohort study, which included healthy full-term newborns (> 200) with at least one first relative with biopsy-verified CD. The present study includes cases of CD (n = 10) and the best-matched controls (n = 10) who did not develop the disease after 5-year follow-up. Fecal microbiota, assessed by high-throughput 16S rRNA gene amplicon sequencing, and immune parameters were profiled at 4 and 6 months of age and related to CD onset.

Results

The microbiota of infants who remained healthy showed an inc

SUBMITTER: Olivares M 

PROVIDER: S-EPMC5819212 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature