Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats.

ABSTRACT:

Background

Polychlorinated biphenyls (PCBs) are persistent organic environmental contaminants and known endocrine-disrupting chemicals (EDCs). Previous studies demonstrated that developmental exposure to the weakly estrogenic PCB mixture Aroclor 1221 (A1221) in Sprague-Dawley rats altered sexual development, adult reproductive physiology and body weight. The current study tested the hypothesis that prenatal A1221 exposure not only disrupts these endpoints within an exposed individual's (F₁ generation) lifespan, but may also affect subsequent generations (F₂-F₃).

Methods

We treated pregnant female rats on embryonic days (E) 16 and E18 with A1221 (1 mg/kg), estradiol benzoate (50 μg/kg, positive estrogenic control), or vehicle (3% DMSO in sesam

SUBMITTER: Mennigen JA 

PROVIDER: S-EPMC5819226 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature