Construction of an organelle-like nanodevice via supramolecular self-assembly for robust biocatalysts.

ABSTRACT:

Background

When using the microbial cell factories for green manufacturing, several important issues need to be addressed such as how to maintain the stability of biocatalysts used in the bioprocess and how to improve the synthetic efficiency of the biological system. One strategy widely used during natural evolution is the creation of organelles which can be used for regional control. This kind of compartmentalization strategy has inspired the design of artificial organelle-like nanodevice for synthetic biology and "green chemistry".

Results

Mimicking the natural concept of functional compartments, here we show that the engineered thermostable ketohydroxyglutarate aldolase from Thermotoga maritima could be developed as a general platform for nanoreactor design via supramole

SUBMITTER: Li H 

PROVIDER: S-EPMC5819227 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature