Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes.

ABSTRACT: A substantial proportion of influenza-related childhood deaths are due to infection with influenza B viruses, which co-circulate in the human population as two antigenically distinct lineages defined by the immunodominant receptor binding protein, haemagglutinin. While broadly cross-reactive, protective monoclonal antibodies against the haemagglutinin of influenza B viruses have been described, none targeting the neuraminidase, the second most abundant viral glycoprotein, have been reported. Here, we analyse a panel of five murine anti-neuraminidase monoclonal antibodies that demonstrate broad binding, neuraminidase inhibition, in vitro antibody-dependent cell-mediated cytotoxicity and in vivo protection against influenza B viruses belonging to both haemagglutinin lineages and spanning ove

SUBMITTER: Wohlbold TJ 

PROVIDER: S-EPMC5819343 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature