STAC proteins associate to the IQ domain of Ca_V1.2 and inhibit calcium-dependent inactivation.

ABSTRACT: The adaptor proteins STAC1, STAC2, and STAC3 represent a newly identified family of regulators of voltage-gated calcium channel (Ca_V) trafficking and function. The skeletal muscle isoform STAC3 is essential for excitation-contraction coupling and its mutation causes severe muscle disease. Recently, two distinct molecular domains in STAC3 were identified, necessary for its functional interaction with Ca_V1.1: the C1 domain, which recruits STAC proteins to the calcium channel complex in skeletal muscle triads, and the SH3-1 domain, involved in excitation-contraction coupling. These interaction sites are conserved in the three STAC proteins. However, the molecular domain in Ca_V1 channels interacting with the STAC C1 domain and the possible role of this interact

SUBMITTER: Campiglio M 

PROVIDER: S-EPMC5819422 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature