Ontology highlight
ABSTRACT:
SUBMITTER: Stegemann-Koniszewski S
PROVIDER: S-EPMC5819576 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Stegemann-Koniszewski Sabine S Behrens Sarah S Boehme Julia D JD Hochnadel Inga I Riese Peggy P Guzmán Carlos A CA Kröger Andrea A Schreiber Jens J Gunzer Matthias M Bruder Dunja D
Frontiers in immunology 20180213
The innate immune system senses influenza A virus (IAV) through different pathogen-recognition receptors including Toll-like receptor 7 (TLR7). Downstream of viral recognition natural killer (NK) cells are activated as part of the anti-IAV immune response. Despite the known decisive role of TLR7 for NK cell activation by therapeutic immunostimulatory RNAs, the contribution of TLR7 to the NK cell response following IAV infection has not been addressed. We have analyzed lung cytokine responses as ...[more]