Long non-coding RNA HOTAIR polymorphism and susceptibility to cancer: an updated meta-analysis.

ABSTRACT:

Background

An increasing number of publications are drawing attention to the associations between six common polymorphisms in HOX transcript anti-sense RNA (HOTAIR) and the risk of cancers, while these results have been controversial and inconsistent. We conducted an up-to-date meta-analysis to pool eligible studies and to further explore the possible relationships between HOTAIR polymorphisms (rs920778, rs7958904, rs12826786, 4,759,314, rs874945, and rs1899663) and cancer risk.

Methods

A systematic retrieval was conducted up to 1 July 2017 in the PubMed, Web of Science, and CNKI databases. Eighteen eligible publications including 45 case-control studies with 58,601subjects were enrolled for assessing the associations between the 6 polymorphisms in HOTAIR and cancer risk. Po

SUBMITTER: Li J 

PROVIDER: S-EPMC5819648 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature