Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients.

ABSTRACT:

Background

Chronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigenesis and cell cycle regulation. Persistence of HBV DNA contributes to cirrhosis and hepatocellular carcinoma (HCC) in CHB patients. Histone acetyltransferase enhances HBV replication, however the precise underlying mechanism of hMOF in HBV replication in CHB patients remains to be explored. This study aims to investigate the correlation between hepatic hMOF and HBV DNA replication in CHB patients, and may provide new insights towards the treatment of CHB patients.

Methods

hMOF in liver biopsy (CHB, n = 33 HBeAg⁺; n = 20 HBeAg^-, and three

SUBMITTER: Chen L 

PROVIDER: S-EPMC5819663 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature