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Empirical evidence that metabolic theory describes the temperature dependency of within-host parasite dynamics.

ABSTRACT: The complexity of host-parasite interactions makes it difficult to predict how host-parasite systems will respond to climate change. In particular, host and parasite traits such as survival and virulence may have distinct temperature dependencies that must be integrated into models of disease dynamics. Using experimental data from Daphnia magna and a microsporidian parasite, we fitted a mechanistic model of the within-host parasite population dynamics. Model parameters comprising host aging and mortality, as well as parasite growth, virulence, and equilibrium abundance, were specified by relationships arising from the metabolic theory of ecology. The model effectively predicts host survival, parasite growth, and the cost of infection across temperature while using less than half the parameters compared to modeling temperatures discretely. Our results serve as a proof of concept that linking simple metabolic models with a mechanistic host-parasite framework can be used to predict temperature responses of parasite population dynamics at the within-host level.

SUBMITTER: Kirk D

PROVIDER: S-EPMC5819823 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature

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Empirical evidence that metabolic theory describes the temperature dependency of within-host parasite dynamics.

Kirk Devin D Jones Natalie N Peacock Stephanie S Phillips Jessica J Molnár Péter K PK Krkošek Martin M Luijckx Pepijn P

PLoS biology 20180207 2

The complexity of host-parasite interactions makes it difficult to predict how host-parasite systems will respond to climate change. In particular, host and parasite traits such as survival and virulence may have distinct temperature dependencies that must be integrated into models of disease dynamics. Using experimental data from Daphnia magna and a microsporidian parasite, we fitted a mechanistic model of the within-host parasite population dynamics. Model parameters comprising host aging and ...[more]

PMID: 29415043

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Project description:I study the co-evolution between public opinion and party policy in situations of crises by investigating a policy U-turn of a major Austrian right-wing party (FPÖ) during the Covid-19 pandemic. My analysis suggests the existence of both i) a "Downsian" effect, which causes voters to adapt their party preferences based on policy congruence and ii) a "party identification" effect, which causes partisans to realign their policy preferences based on "their" party's platform. Specifically, I use individual-level panel data to show that i) "corona skeptical" voters who did not vote for the FPÖ in the pre-Covid-19 elections of 2019 were more likely to vote for the party after it embraced "corona populism", and ii) beliefs of respondents who declared that they voted for the FPÖ in 2019 diverged from the rest of the population in three out of four health-related dimensions only after the turn, causing them to underestimate the threat posed by Covid-19 compared to the rest of the population. Using aggregate-level panel data, I study whether the turn has produced significant behavioral differences which could be observed in terms of reported cases and deaths per capita. Paradoxically, after the turn the FPÖ vote share is significantly positively correlated with deaths per capita, but not with the reported number of infections. I hypothesize that this can be traced back to a self-selection bias in testing, which causes a correlation between the number of "corona skeptics" and the share of unreported cases after the turn. I find empirical support for this hypothesis in individual-level data from a Covid-19 prevalence study that involves information about participants' true vs. reported infection status. I finally study a simple heterogeneous mixing epidemiological model and show that a testing bias can indeed explain the apparent paradox of an increase in deaths without an increase in reported cases. My results can, among others, be used to enrich formal analyses regarding the co-evolution between voter and party behavior.

Dataset Information

Empirical evidence that metabolic theory describes the temperature dependency of within-host parasite dynamics.

Publications

Empirical evidence that metabolic theory describes the temperature dependency of within-host parasite dynamics.

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