Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children.

ABSTRACT:

Introduction

Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with β-blockade or testosterone analogs showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness, and protein turnover are unknown. In this placebo-controlled randomized trial, we hypothesize that RET combined with oxandrolone and propranolol (Oxprop) will improve muscle mass and function and protein turnover in severely burned children compared with burned children undergoing the same RET with a placebo.

Methods

SUBMITTER: Chao T 

PROVIDER: S-EPMC5820183 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature