Targeted Temperature Management After Cardiac Arrest: Systematic Review and Meta-analyses.

ABSTRACT:

Background

Targeted temperature management (TTM) with therapeutic hypothermia is an integral component of postarrest care for survivors. However, recent randomized controlled trials (RCTs) have failed to demonstrate the benefit of TTM on clinical outcomes. We sought to determine if the pooled data from available RCTs support the use of prehospital and/or in-hospital TTM after cardiac arrest.

Methods

A comprehensive search of SCOPUS, Elsevier's abstract and citation database of peer-reviewed literature, from 1966 to November 2016 was performed using predefined criteria. Therapeutic hypothermia was defined as any strategy that aimed to cool post-cardiac arrest survivors to a temperature ≤34°C. Normothermia was temperature of ≥36°C. We compared mortality and neurologic outcomes

SUBMITTER: Kalra R 

PROVIDER: S-EPMC5820193 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature