Amygdala hyper-connectivity in a mouse model of unpredictable early life stress.

ABSTRACT: Childhood maltreatment is associated with a wide range of psychopathologies including anxiety that emerge in childhood and in many cases persist in adulthood. Increased amygdala activation in response to threat and abnormal amygdala connectivity with frontolimbic brain regions, such as the hippocampus and the prefrontal cortex, are some of the most consistent findings seen in individuals exposed to childhood maltreatment. The underlying mechanisms responsible for these changes are difficult to study in humans but can be elucidated using animal models of early-life stress. Such studies are especially powerful in the mouse where precise control of the genetic background and the stress paradigm can be coupled with resting-state fMRI (rsfMRI) to map abnormal connectivity in circuits that regul

SUBMITTER: Johnson FK 

PROVIDER: S-EPMC5820270 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature