A Score for Risk of Thrombolysis-Associated Hemorrhage Including Pretreatment with Statins.

ABSTRACT:

Background

Symptomatic intracranial hemorrhage (sICH) after intravenous thrombolysis with recombinant tissue-plasminogen activator (rt-PA) for acute ischemic stroke is associated with a poor functional outcome. We aimed to develop a score assessing risk of sICH including novel putative predictors-namely, pretreatment with statins and severe renal impairment.

Methods

We analyzed our local cohort (Berlin) of patients receiving rt-PA for acute ischemic stroke between 2006 and 2016. Outcome was sICH according to ECASS-III criteria. A multiple regression model identified variables associated with sICH and receiver operating characteristics were calculated for the best discriminatory model for sICH. The model was validated in an independent thrombolysis cohort (Basel).

Results<

SUBMITTER: Erdur H 

PROVIDER: S-EPMC5820302 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature