Microstructure Characterization of Bone Metastases from Prostate Cancer with Diffusion MRI: Preliminary Findings.

ABSTRACT:

Purpose

To examine the usefulness of rich diffusion protocols with high b-values and varying diffusion time for probing microstructure in bone metastases. Analysis techniques including biophysical and mathematical models were compared with the clinical apparent diffusion coefficient (ADC).

Methods

Four patients were scanned using 13 b-values up to 3,000 s/mm² and diffusion times ranging 18-52 ms. Data were fitted to mono-exponential ADC, intravoxel incoherent motion (IVIM), Kurtosis and Vascular, extracellular, and restricted diffusion for cytometry in tumors (VERDICT) models. Parameters from the models were compared using correlation plots.

Results

ADC and IVIM did not fit the data well, failing to capture the signal at high b-values.

SUBMITTER: Bailey C 

PROVIDER: S-EPMC5820304 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature