Postnatal myocardium remodelling generates inhomogeneity in the architecture of the ventricular mass.

ABSTRACT:

Background

The 3D architecture of the ventricular mass is poorly known, although in vivo imaging techniques show the physiological inhomogeneity of ventricular walls mechanics. Polarized light imaging makes it possible to quantitatively analyse the myosin filament orientation.

Aims

In this paper, we focus on the study the 3D architecture and regional isotropy of myocardial cells.

Methods

Twenty normal human hearts, 10 from the perinatal period and 10 from the post-neonatal period were studied by polarized light microscopy. In each voxel of the ventricular mass (90 × 90 × 500 µm) the principal orientation segment was automatically and unambiguously extracted as well as a regional isotropy index (regional orientation tensor of the voxel neighbourhood).

Results

Du

SUBMITTER: Jouk PS 

PROVIDER: S-EPMC5820407 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature