Rapid changes in serum cytokines and chemokines in response to inactivated influenza vaccination.

ABSTRACT:

Background

The timing of host cytokine responses to influenza vaccination is poorly understood.

Objectives

We examined serum cytokine kinetics following inactivated trivalent influenza vaccine (TIV) to better understand potential relationships between markers of inflammation and TIV-related side effects.

Patients/methods

Twenty healthy adult subjects received TIV. Cytokines/chemokines were assessed in intervals from 3 hours to 14 days. Antibody titers were measured at baseline and Day 14.

Results

Serum cytokine responses to TIV were evident as early as 3 hours post-immunization. Compared to baseline, IFN-γ and IP-10 were significantly elevated 7 hours after TIV administration. Both remained elevated and peaked between 16 and 24 hours before returning to baselin

SUBMITTER: Talaat KR 

PROVIDER: S-EPMC5820426 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature