Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis.

ABSTRACT:

Background

The humoral system is activated and various cytokines are released due to infections in tissues and traumatic damage. Nuclear factor-kappa B dimers are encoded by nuclear factor-kappa B genes and regulate transcription of several crucial proteins of inflammation such as tumour necrosis factor-alpha.

Aims

To investigate the possible effect of polymorphisms on tumour necrosis factor-alpha serum levels with clinical and prognostic parameters of sepsis by determining the nuclear factor-kappa B-1-94 ins/del ATTG and tumour necrosis factor-alpha (-308 G/A) gene polymorphisms and tumour necrosis factor-alpha serum levels.

Study design

Case-control study.

Methods

Seventy-two patients with sepsis and 104 healthy controls were included in the study. In order t

SUBMITTER: Acar L 

PROVIDER: S-EPMC5820445 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature