Effects of four single nucleotide polymorphisms of EZH2 on cancer risk: a systematic review and meta-analysis.

ABSTRACT:

Background

Although the relationship between several single nucleotide polymorphisms (SNPs) of the oncogene EZH2 and cancer risk has been assessed by some case-control studies, results of subsequent studies are controversial. Sample sizes from single-center studies are also limited, thereby providing unreliable findings. Hence, we conducted a comprehensive search and meta-analysis to evaluate the associations between EZH2 SNPs and cancer risk.

Materials and methods

A comprehensive literature search for studies focusing on EZH2 SNPs and cancer risk was conducted on PubMed, Web of Science, Embase, and China National Knowledge Infrastructure online databases. Genotype data were extracted and examined through a meta-analysis, and pooled odds ratios (ORs) wit

SUBMITTER: Ling Z 

PROVIDER: S-EPMC5820467 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature