Identification of Shared Molecular Signatures Indicate the Susceptibility of Endometriosis to Multiple Sclerosis.

ABSTRACT: Women with endometriosis (EMS) appear to be at a higher risk of developing other autoimmune diseases predominantly multiple sclerosis (MS). Though EMS and MS are evidently diverse in their phenotype, they are linked by a common autoimmune condition or immunodeficiency which could play a role in the expansion of endometriosis and possibly increase the risk of developing MS in women with EMS. However, the common molecular links connecting EMS with MS are still unclear. We conducted a meta-analysis of microarray experiments focused on EMS and MS with their respective controls. The GEO2R web application discovered a total of 711 and 1516 genes that are differentially expressed across the experimental conditions in EMS and MS, respectively with 129 shared DEGs between them. The functional enric

SUBMITTER: Katiyar A 

PROVIDER: S-EPMC5820528 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature