Systematic Identification of Intracellular-Translocated Candidate Effectors in Edwardsiella piscicida.

ABSTRACT: Many bacterial pathogens inject effectors directly into host cells to target a variety of host cellular processes and promote bacterial dissemination and survival. Identifying the bacterial effectors and elucidating their functions are central to understanding the molecular pathogenesis of these pathogens. Edwardsiella piscicida is a pathogen with a wide host range, and very few of its effectors have been identified to date. Here, based on the genes significantly regulated by macrophage infection, we identified 25 intracellular translocation-positive candidate effectors, including all five previously reported effectors, namely EseG, EseJ, EseH, EseK, and EvpP. A subsequent secretion analysis revealed diverse secretion patterns for the 25 effector candidates, suggesting that multiple transp

SUBMITTER: Zhang L 

PROVIDER: S-EPMC5820615 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature