Reproducibility of clinical research in critical care: a scoping review.

ABSTRACT:

Background

The ability to reproduce experiments is a defining principle of science. Reproducibility of clinical research has received relatively little scientific attention. However, it is important as it may inform clinical practice, research agendas, and the design of future studies.

Methods

We used scoping review methods to examine reproducibility within a cohort of randomized trials examining clinical critical care research and published in the top general medical and critical care journals. To identify relevant clinical practices, we searched the New England Journal of Medicine, The Lancet, and JAMA for randomized trials published up to April 2016. To identify a comprehensive set of studies for these practices, included articles informed secondary searches within other

SUBMITTER: Niven DJ 

PROVIDER: S-EPMC5820784 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature