Leukocyte telomere length in paediatric critical illness: effect of early parenteral nutrition.

ABSTRACT:

Background

Children who have suffered from critical illnesses that required treatment in a paediatric intensive care unit (PICU) have long-term physical and neurodevelopmental impairments. The mechanisms underlying this legacy remain largely unknown. In patients suffering from chronic diseases hallmarked by inflammation and oxidative stress, poor long-term outcome has been associated with shorter telomeres. Shortened telomeres have also been reported to result from excessive food consumption and/or unhealthy nutrition. We investigated whether critically ill children admitted to the PICU have shorter-than-normal telomeres, and whether early parenteral nutrition (PN) independently affects telomere length when adjusting for known determinants of telomere length.

Methods

Telomer

SUBMITTER: Verstraete S 

PROVIDER: S-EPMC5820800 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature