Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells.

ABSTRACT: A recent breakthrough showing that direct trans-differentiation of chondrocytes into bone cells commonly occurs during endochondral bone formation in the growth plate, articular cartilage, and mandibular condylar cartilage suggests that chondrogenesis and osteogenesis are likely one continuous biological process instead of two separate processes. Yet, gene regulation of this cell transformation is largely unclear. Here, we employed cartilage-specific β-catenin loss-of-function (β-catenin ^fx/fx ) and gain-of-function (β-catenin ^{fx(exon3)/ fx(exon3)} ) models in the R26R^Tomato background (for better tracing the cell fate of chondrocytes) to study the role of β-catenin in cell trans-differentiation. Using histological, immunoh

SUBMITTER: Jing Y 

PROVIDER: S-EPMC5821044 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature