Nanoparticle-Based Celecoxib and Plumbagin for the Synergistic Treatment of Melanoma.

ABSTRACT: Using multiple drugs to kill cancer cells can decrease drug resistance development. However, this approach is frequently limited by the bioavailability and toxicity of the combined agents and delivery at ratios to specific locations that synergistically kill cancer cells. Loading the individual agents into a nanoparticle that releases the drugs at synergizing ratios at a single location is one approach to resolve this concern. Celecoxib and plumbagin are two drugs that were identified from a screen to synergistically kill melanoma cells compared with normal cells. Combined use of these agents by traditional approaches was not possible due to poor bioavailability and toxicologic concerns. This study details the development of a nanoliposomal-based agent containing celecoxib and plumbagin, c

SUBMITTER: Gowda R 

PROVIDER: S-EPMC5821064 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature