CDK activity provides temporal and quantitative cues for organizing genome duplication.

ABSTRACT: In eukaryotes, the spatial and temporal organization of genome duplication gives rise to distinctive profiles of replication origin usage along the chromosomes. While it has become increasingly clear that these programs are important for cellular physiology, the mechanisms by which they are determined and modulated remain elusive. Replication initiation requires the function of cyclin-dependent kinases (CDKs), which associate with various cyclin partners to drive cell proliferation. Surprisingly, although we possess detailed knowledge of the CDK regulators and targets that are crucial for origin activation, little is known about whether CDKs play a critical role in establishing the genome-wide pattern of origin selection. We have addressed this question in the fission yeast, taking advanta

SUBMITTER: Perrot A 

PROVIDER: S-EPMC5821308 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature