Epigenome comparisons reveal linkage between gene expression and postnatal remodeling of chromatin domain topology.

ABSTRACT: Substantial evidence has accumulated linking epigenome change to alterations in stem cell function during postnatal development and aging. Yet much remains to be learned about causal relationships, and large gaps remain in our understanding of epigenome-transcriptome interactions. Here we investigate structural features of large histone H3K27me3-enriched regions in human stem cell-like monocytes and their dendritic cell derivatives, where the H3K27me3 modification is considered to demarcate Polycomb (PcG) domains. Both differentiation- and postnatal development-related change are explored, initially by confirming expected reciprocal relationships between transcript abundance and span of PcG domains overlapping transcribed regions. PcG-associated postnatal transcriptome change specific to t

SUBMITTER: Howard BH 

PROVIDER: S-EPMC5821309 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature