Role of T1 mapping as a complementary tool to T2* for non-invasive cardiac iron overload assessment.

ABSTRACT:

Background

Iron overload-related heart failure is the principal cause of death in transfusion dependent patients, including those with Thalassemia Major. Linking cardiac siderosis measured by T2* to therapy improves outcomes. T1 mapping can also measure iron; preliminary data suggests it may have higher sensitivity for iron, particularly for early overload (the conventional cut-point for no iron by T2* is 20ms, but this is believed insensitive). We compared T1 mapping to T2* in cardiac iron overload.

Methods

In a prospectively large single centre study of 138 Thalassemia Major patients and 32 healthy controls, we compared T1 mapping to dark blood and bright blood T2* acquired at 1.5T. Linear regression analysis was used to assess the association of T2* and T1. A "moving wind

SUBMITTER: Torlasco C 

PROVIDER: S-EPMC5821344 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature