Using biomimetic polymers in place of noncollagenous proteins to achieve functional remineralization of dentin tissues.

ABSTRACT: In calcified tissues such as bones and teeth, mineralization is regulated by an extracellular matrix, which includes non-collagenous proteins (NCP). This natural process has been adapted or mimicked to restore tissues following physical damage or demineralization by using polyanionic acids in place of NCPs, but the remineralized tissues fail to fully recover their mechanical properties. Here we show that pre-treatment with certain amphiphilic peptoids, a class of peptide-like polymers consisting of N-substituted glycines that have defined monomer sequences, enhances ordering and mineralization of collagen and induces functional remineralization of dentin lesions in vitro. In the vicinity of dentin tubules, the newly formed apatite nano-crystals are co-aligned with the c-axis

SUBMITTER: Chien YC 

PROVIDER: S-EPMC5821432 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature