Molecular coordination of <i>Staphylococcus aureus</i> cell division.

ABSTRACT: The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen Staphylococcus aureus is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core divisi

SUBMITTER: Lund VA 

PROVIDER: S-EPMC5821461 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature