Chronic consumption of a western diet modifies the DNA methylation profile in the frontal cortex of mice.

ABSTRACT: In our previous work in mice, we have shown that chronic consumption of a Western diet (WD; 42% kcal fat, 0.2% total cholesterol and 34% sucrose) is correlated with impaired cognitive function. Cognitive decline has also been associated with alterations in DNA methylation. Additionally, although there have been many studies analyzing the effect of maternal consumption of a WD on DNA methylation in the offspring, few studies have analyzed how an individual's consumption of a WD can impact his/her DNA methylation. Since the frontal cortex is involved in the regulation of cognitive function and is often affected in cases of cognitive decline, this study aimed to examine how chronic consumption of a WD affects DNA methylation in the frontal cortex of mice. Eight-week-old male mice were fed eit

SUBMITTER: Yokoyama AS 

PROVIDER: S-EPMC5821526 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature