A mutational comparison of adult and adolescent and young adult (AYA) colon cancer.

ABSTRACT:

Background

It is possible that the relative lack of progress in treatment outcomes among adolescent and young adult (AYA) patients with cancer is caused by a difference in disease biology compared with the corresponding diseases in younger and older individuals. There is evidence that colon cancer is more aggressive and has a poorer prognosis in AYA patients than in older adult patients.

Methods

To further understand the molecular basis for this difference, whole-exome sequencing was conducted on a cohort of 30 adult, 30 AYA, and 2 pediatric colon cancers.

Results

A statistically significant difference in mutational frequency was observed between AYA and adult samples in 43 genes, including ROBO1, MYC binding protein 2 (MYCBP2), breast cancer 2 (early onset) (BRCA2),

SUBMITTER: Tricoli JV 

PROVIDER: S-EPMC5821537 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature