IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4⁺ T Cell Migration.

ABSTRACT: Chronic inflammatory demyelinating polyneuropathy (CIDP) is a debilitating condition caused by autoimmune demyelination of peripheral nerves. CIDP is associated with increased IL-10, a cytokine with well-described anti-inflammatory effects. However, the role of IL-10 in CIDP is unclear. In this study, we demonstrate that IL-10 paradoxically exacerbates autoimmunity against peripheral nerves. In IL-10-deficient mice, protection from neuropathy was associated with an accrual of highly activated CD4⁺ T cells in draining lymph nodes and absence of infiltrating immune cells in peripheral nerves. Accumulated CD4⁺ T cells in draining lymph nodes of IL-10-deficient mice expressed lower sphingosine-1-phosphate receptor 1 (S1pr1), a protein important in lymphocyte egress

SUBMITTER: Smith CJ 

PROVIDER: S-EPMC5821539 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature