Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia.

ABSTRACT:

Background

The early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm² ), and health-related quality of life (HRQL). We assessed the capacity of a physical therapy and motivation-based intervention, beginning after diagnosis and continuing through the end of treatment, to positively modify these factors.

Procedure

A 2.5-year randomized controlled trial of 73 patients aged 4-18.99 years within 10 days of ALL diagnosis assessed BMD at baseline (T⁰ ) and end of therapy (T³ ), strength, range of motion, endurance, motor skills, and HRQL at baseline (T⁰ ), 8 (T¹ ), 15 (T² ), and 135 (T³ ) weeks.

Results

There were no signif

SUBMITTER: Cox CL 

PROVIDER: S-EPMC5821547 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature