Accuracy, repeatability, and interplatform reproducibility of T₁ quantification methods used for DCE-MRI: Results from a multicenter phantom study.

ABSTRACT:

Purpose

To determine the in vitro accuracy, test-retest repeatability, and interplatform reproducibility of T₁ quantification protocols used for dynamic contrast-enhanced MRI at 1.5 and 3 T.

Methods

A T₁ phantom with 14 samples was imaged at eight centers with a common inversion-recovery spin-echo (IR-SE) protocol and a variable flip angle (VFA) protocol using seven flip angles, as well as site-specific protocols (VFA with different flip angles, variable repetition time, proton density, and Look-Locker inversion recovery). Factors influencing the accuracy (deviation from reference NMR T₁ measurements) and repeatability were assessed using general linear mixed models. Interplatform reproducibility was assessed using coefficients of variation.<

SUBMITTER: Bane O 

PROVIDER: S-EPMC5821553 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature