Differential Expression of CD8⁺ T Cell Cytotoxic Effector Molecules in Blood and Gastrointestinal Mucosa in HIV-1 Infection.

ABSTRACT: We previously reported that CD8⁺ T cells in human gastrointestinal mucosa exhibit reduced perforin expression and weak or impaired cytotoxic capacity compared with their counterparts in blood. Nevertheless, these cells degranulate and express cytokines and chemokines in response to cognate Ag. In addition to weak expression of perforin, earlier studies suggested differential regulation of perforin and granzymes (Gzms), with GzmA and B expressed by significantly higher percentages of mucosal CD8⁺ T cells than perforin. However, this topic has not been fully explored. The goal of this study was to elucidate the expression and coexpression patterns of GzmA, B, and K in conjunction with perforin in rectosigmoid CD8⁺ T cells during HIV-1 infection. We found that

SUBMITTER: Kiniry BE 

PROVIDER: S-EPMC5821568 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature