MEDI+0: Morphology enabled dipole inversion with automatic uniform cerebrospinal fluid zero reference for quantitative susceptibility mapping.

ABSTRACT:

Purpose

To develop a quantitative susceptibility mapping (QSM) method with a consistent zero reference using minimal variation in cerebrospinal fluid (CSF) susceptibility.

Theory and methods

The ventricular CSF was automatically segmented on the R2* map. An L₂ -regularization was used to enforce CSF susceptibility homogeneity within the segmented region, with the averaged CSF susceptibility as the zero reference. This regularization for CSF homogeneity was added to the model used in a prior QSM method (morphology enabled dipole inversion [MEDI]). Therefore, the proposed method was referred to as MEDI+0 and compared with MEDI in a numerical simulation, in multiple sclerosis (MS) lesions, and in a reproducibility study in healthy subjects.

Results

In both the

SUBMITTER: Liu Z 

PROVIDER: S-EPMC5821583 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature