Biased Generation and In Situ Activation of Lung Tissue-Resident Memory CD4 T Cells in the Pathogenesis of Allergic Asthma.

ABSTRACT: Asthma is a chronic inflammatory disease mediated by allergen-specific CD4 T cells that promote lung inflammation through recruitment of cellular effectors into the lung. A subset of lung T cells can persist as tissue-resident memory T cells (TRMs) following infection and allergen induction, although the generation and role of TRM in asthma persistence and pathogenesis remain unclear. In this study, we used a mouse model of chronic exposure to intranasal house dust mite (HDM) extract to dissect how lung TRMs are generated and function in the persistence and pathogenesis of allergic airway disease. We demonstrate that both CD4⁺ and CD8⁺ T cells infiltrate into the lung tissue during acute HDM exposure; however, only CD4⁺ TRMs, and not CD8⁺ TRMs, p

SUBMITTER: Turner DL 

PROVIDER: S-EPMC5821590 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature