Oxidative Stress and Apoptosis in Benzo[a]pyrene-Induced Neural Tube Defects.

ABSTRACT: Neural tube defects (NTDs) are among the most common and severe congenital malformations and result from incomplete closure of the neural tube during early development. Maternal exposure to polycyclic aromatic hydrocarbons (PAHs) has been suggested to be a risk factor for NTDs and previous studies imply that the mechanism underlying the association between PAH exposure and NTDs may involve oxidative stress and apoptosis. The objectives of this study were to investigate whether there is a direct effect of maternal benzo[α] pyrene (BaP) exposure on the closure of the neural tube in mice, and to examine the underlying mechanisms by combining animal experiments and human subject studies. We found that intraperitoneal injection of BaP from embryonic day 7 at a dose of 250 mg kg^-1 ind

SUBMITTER: Lin S 

PROVIDER: S-EPMC5821680 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature