Reverse Myocardial Remodeling Following Valve Replacement in Patients With Aortic Stenosis.

ABSTRACT:

Background

Left ventricular (LV) hypertrophy, a key process in human cardiac disease, results from cellular (hypertrophy) and extracellular matrix expansion (interstitial fibrosis).

Objectives

This study sought to investigate whether human myocardial interstitial fibrosis in aortic stenosis (AS) is plastic and can regress.

Methods

Patients with symptomatic, severe AS (n = 181; aortic valve area index 0.4 ± 0.1 cm²/m²) were assessed pre-aortic valve replacement (AVR) by echocardiography (AS severity, diastology), cardiovascular magnetic resonance (CMR) (for volumes, function, and focal or diffuse fibrosis), biomarkers (N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin T), and the 6-min walk test. CMR was used to measure the e

SUBMITTER: Treibel TA 

PROVIDER: S-EPMC5821681 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature