The UK Paediatric Familial Hypercholesterolaemia Register: Statin-related safety and 1-year growth data.

ABSTRACT:

Background

For children with familial hypercholesterolemia (FH), UK guidelines recommend consideration of statin therapy by age 10 years and dietary and lifestyle advice to maintain an ideal body weight.

Objectives

The objective of the study is to use the UK Paediatric Familial Hypercholesterolemia Register to determine: (1) the prevalence of plasma markers of liver toxicity and muscle damage in statin-treated FH children; (2) the prevalence of obesity in FH children compared to the UK general population; and (3) to compare growth rates in statin-treated and nontreated children.

Methods

Differences in registration and 1-year characteristics were compared by Mann-Whitney U tests. Age and gender body mass index percentiles were compared to UK children's growth charts.

SUBMITTER: Humphries SE 

PROVIDER: S-EPMC5821682 | biostudies-literature | 2018 Jan - Feb

REPOSITORIES: biostudies-literature