Impact of Alcohol Intake and Drinking Patterns on Mortality From All Causes and Major Causes of Death in a Japanese Population.

ABSTRACT:

Background

We examined the associations of alcohol consumption and liver holidays with all-cause mortality and with mortality due to cancer, heart disease, cerebrovascular disease, respiratory disease, and injury using a large-scale prospective study in Japan.

Methods

We followed 102,849 Japanese who were aged between 40 and 69 years at baseline for 18.2 years on average, during which 15,203 deaths were reported. Associations between alcohol intake and mortality risk were assessed using a Cox proportional hazards model, with analysis by the number of liver holidays (in which a person abstains from drinking for several days a week).

Results

A J-shaped association was observed between alcohol intake and total mortality in men (nondrinkers: reference; occasional drinkers

SUBMITTER: Saito E 

PROVIDER: S-EPMC5821691 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature