Distinguishing Human Peripheral Blood NK Cells from CD56^dimCD16^dimCD69⁺CD103⁺ Resident Nasal Mucosal Lavage Fluid Cells.

ABSTRACT: Natural killer (NK) cells are members of the innate lymphoid cells group 1 (ILC1s), which play a critical role in innate host defense against viruses and malignancies. While many studies have examined the role of circulating peripheral blood (PB) CD56⁺ NK cells, little is known about the resident CD56⁺ cell population. Therefore, matched CD56⁺ cells from nasal lavage fluid (NLF) and PB of smokers and non-smokers were compared phenotypically, via flow cytometry, and functionally, via NK-cell specific gene expression. NLF and PB CD56⁺ cells had similar expression of CD56, but differentially expressed tissue residency (CD69 and CD103) and cytotoxicity (CD16) markers. In addition, NLF CD56^dim cells expressed lower levels of cytotoxicity-as

SUBMITTER: Rebuli ME 

PROVIDER: S-EPMC5821812 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature