Spatial geometry of stem cell proliferation in the adult hippocampus.

ABSTRACT: The modes of stem cell divisions (e.g., symmetric vs. asymmetric) can have a profound impact on the number of progeny and tissue growth, repair, and function. This is particularly relevant for adult neural stem cells, since stem cell-derived neurons affect cognitive and mental states, resistance to stress and disease, and response to therapies. Here we show that although dividing stem cells in the adult hippocampus display a certain bias towards paired distribution (which could imply the prevalence of symmetric divisions), this bias already exists in the distribution of the general population of stem cells and may be responsible for the perceived occurrence of symmetric stem cell divisions. Remarkably, the bias in the distribution of stem cells decreases with age. Our results argue that th

SUBMITTER: Mineyeva OA 

PROVIDER: S-EPMC5821870 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature