Polymorphisms in Vitamin D Receptor Genes in Association with Childhood Autism Spectrum Disorder.

ABSTRACT: Both genetic and environmental factors have been implicated in the etiology of autism spectrum disorder (ASD). This case-control study aimed to determine the association of single-nucleotide polymorphisms (SNPs) rs731276 (TaqI), rs1568820 (Cdx2), rs1544410 (BsmI), and rs2228570 (FokI) in the vitamin D receptor (VDR) gene with susceptibility of childhood ASD and severity of the disease. A total of 201 children with ASD and 200 healthy controls from the Han Chinese population were recruited. SNP genotyping was carried out by TaqMan probe-based real-time PCR using genomic DNA extracted from blood cells. Among four examined SNPs, only the CT genotype (odds ratio (OR) = 1.96, 95% confidence interval (CI) = 1.05-3.68, P = 0.0351) and the C allele (OR = 1.88, 95% CI = 1.02-3.46, P =

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC5821970 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature