Vitronectin as a Micromanager of Cell Response in Material-Driven Fibronectin Nanonetworks.

ABSTRACT: Surface functionalization strategies of synthetic materials for regenerative medicine applications comprise the development of microenvironments that recapitulate the physical and biochemical cues of physiological extracellular matrices. In this context, material-driven fibronectin (FN) nanonetworks obtained from the adsorption of the protein on poly(ethyl acrylate) provide a robust system to control cell behavior, particularly to enhance differentiation. This study aims at augmenting the complexity of these fibrillar matrices by introducing vitronectin, a lower-molecular-weight multifunctional glycoprotein and main adhesive component of serum. A cooperative effect during co-adsorption of the proteins is observed, as the addition of vitronectin leads to increased fibronectin adsorption, im

SUBMITTER: Cantini M 

PROVIDER: S-EPMC5822048 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature